Article
A New Window into the Human Alloresponse.
Transplantation - 1 Aug 2016
DeWolf Susan, Shen Yufeng, Sykes Megan
Abstract excerpt
Alloreactive T lymphocytes are the primary mediators of allograft rejection. The size and diversity of the HLA-alloreactive T cell repertoire has thus far precluded the ability to follow these T cells and thereby to understand their fate in human transplant recipients. This review summarizes the history, challenges, and recent advances in the study of alloreactive T cells. We highlight the historical development...
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