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Article

Qualitative, rather than quantitative, differences between HLA-DQ alleles affect HLA-DQ immunogenicity in organ transplantation.

HLA - 1 Apr 2024

Maguire Chelsea, Crivello Pietro, Fleischhauer Katharina, Isaacson Dylan, Casillas Aurora, Kramer Cynthia S M, Copley Hannah C, Heidt Sebastiaan, Kosmoliaptsis Vasilis, Meneghini Maria, Gmeiner Michael, Schold Jesse, Louzoun Yoram, Tambur Anat R

Abstract excerpt

Prolonging the lifespan of transplanted organs is critical to combat the shortage of this life-saving resource. Chronic rejection, with irreversible demise of the allograft, is often caused by the development of donor-specific HLA antibodies. Currently, enumerating molecular (amino acid) mismatches between recipient and donor is promoted to identify patients at higher risk of developing HLA antibodies, for use in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38575370
DOI: 10.1111/tan.15455
PMCID: PMC11003724

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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