Article
Five HLA-DP molecules frequently expressed in the worldwide human population share a common HLA supertypic binding specificity.
Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2010
Sidney John, Steen Amiyah, Moore Carrie, Ngo Sandy, Chung Jolan, Peters Bjoern, Sette Alessandro
Abstract excerpt
Compared with DR and DQ, knowledge of the binding repertoires and specificities of HLA-DP alleles is somewhat limited. However, a growing body of literature has indicated the importance of DP-restricted responses in the context of cancer, allergy, and infectious disease. In the current study, we developed high-throughput binding assays for the five most common HLA-DPB1 alleles in the general worldwide population....
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