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Article

Allorecognition of HLA-DP by CD4+ T cells is affected by polymorphism in its alpha chain.

Molecular immunology - 1 May 2014

Lauterbach Nina, Crivello Pietro, Wieten Lotte, Zito Laura, Groeneweg Mathijs, Voorter Christina E M, Fleischhauer Katharina, Tilanus Marcel G J

Abstract excerpt

Alloreactivity to HLA-DP molecules, class II heterodimers of an oligomorphic alpha and a polymorphic beta chain, is increasingly being studied due to its relevance in clinical transplantation. We hypothesized that not only polymorphisms in the peptide binding groove encoded by exon 2 of HLA-DPB1, but also in other regions of the molecule and the alpha chain, could play a role in CD4+ T cell allorecognition. To...

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Identifiers

PMID: 24462895
DOI: 10.1016/j.molimm.2013.12.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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