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Alloimmune T cells in transplantation

18 Jun 2017

Abstract excerpt

Alloimmune T cells are central mediators of rejection and graft-versus-host disease in both solid organ and hematopoietic stem cell transplantation. Unique among immune responses in terms of its strength and diversity, the T cell alloresponse reflects extensive genetic polymorphisms between allogeneic donors and recipients, most prominently within the major histocompatibility complex (MHC), which encodes human...

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PMID: 28628037
DOI: 10.1172/jci90595

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