Article

Evolution of DNA methylome from precancer to invasive lung adenocarcinoma

2020-07-28

Abstract excerpt

<title>Abstract</title> <p>The evolution of DNA methylation at genome level and methylation intra-tumor heterogeneity (ITH) during early lung carcinogenesis has not been systematically studied. We performed multiregional reduced representation bisulfite sequencing (RRBS) of 62 resected lung nodules from 39 patients including atypical adenomatous hyperplasia (AAH, n=14), adenocarcinoma in situ (AIS, n=15), minimal...

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Literature Corpus work: 7d97f2ca-9109-5e11-b194-70f46a4b72bd
DOI: 10.21203/rs.3.rs-43354/v1

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