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Article

DNA methylation intratumor heterogeneity in localized lung adenocarcinomas.

Oncotarget - 28 Mar 2017

Quek Kelly, Li Jun, Estecio Marcos, Zhang Jiexin, Fujimoto Junya, Roarty Emily, Little Latasha, Chow Chi-Wan, Song Xingzhi, Behrens Carmen, Chen Taiping, William William N, Swisher Stephen, Heymach John, Wistuba Ignacio, Zhang Jianhua, Futreal Andrew, Zhang Jianjun

Abstract excerpt

Cancers are composed of cells with distinct molecular and phenotypic features within a given tumor, a phenomenon termed intratumor heterogeneity (ITH). Previously, we have demonstrated genomic ITH in localized lung adenocarcinomas; however, the nature of methylation ITH in lung cancers has not been well investigated. In this study, we generated methylation profiles of 48 spatially separated tumor regions from 11...

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Share to Adenocarcinoma
Share to Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Gene Expression Regulation, Neoplastic

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Share to Lung Neoplasms

Share to Neoplasm Recurrence, Local

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Source

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Identifiers

PMID: 28423542
DOI: 10.18632/oncotarget.15777
PMCID: PMC5400640

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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