DNA Methylation Profiling Identifies Subgroups of Lung Adenocarcinoma with Distinct Immune Cell Composition, DNA Methylation Age, and Clinical Outcome.

doi:10.1158/1078-0432.CCR-22-0391

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DNA Methylation Profiling Identifies Subgroups of Lung Adenocarcinoma with Distinct Immune Cell Composition, DNA Methylation Age, and Clinical Outcome.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2022

Guidry Kayla, Vasudevaraja Varshini, Labbe Kristen, Mohamed Hussein, Serrano Jonathan, Guidry Brett W, DeLorenzo Michael, Zhang Hua, Deng Jiehui, Sahu Soumyadip, Almonte Christina, Moreira Andre L, Tsirigos Aristotelis, Papagiannakopoulos Thales, Pass Harvey, Snuderl Matija, Wong Kwok-Kin

Abstract excerpt

PURPOSE: Lung adenocarcinoma (LUAD) is a clinically heterogeneous disease, which is highlighted by the unpredictable recurrence in low-stage tumors and highly variable responses observed in patients treated with immunotherapies, which cannot be explained by mutational profiles. DNA methylation-based classification and understanding of microenviromental heterogeneity may allow stratification into clinically...

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PMID: 35802677
DOI: 10.1158/1078-0432.CCR-22-0391

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