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Article

Multiomic characterization of malignant pulmonary nodules and development of a methylation-based diagnostic Model.

Journal of translational medicine - 8 Jun 2026

Zhou Wei, Xie Tongji, Wu Qingjun, Song Mengmeng, Weng Jianzhen, Zhang Jieli, Gao Xuan, Zheng Min, Wang Zheng, Zhou Yunzhi, Li Yanming

Abstract excerpt

BACKGROUND: The molecular distinction between benign and malignant pulmonary nodules remains a significant diagnostic challenge. While genomic drivers are well studied, multiomic integration of the epigenetic-transcriptional landscape and its translation into noninvasive tools are lacking. METHODS: We performed a multiomic characterization (genomic, epigenomic, and transcriptomic) of 158 pulmonary nodules....

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Topics

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Share to DNA Methylation
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to MIA gene

Share to Lung Neoplasms

Share to Models, Biological

Share to Multiomics

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Source

Open in PubMed Open full text

Identifiers

PMID: 42260586
DOI: 10.1186/s12967-026-08382-w
PMCID: PMC13274191

Genes

EGFR
GDF15
MIA
MYC
PPARG
RASA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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