Article

Evolution of DNA methylome from precancerous lesions to invasive lung adenocarcinomas

2020-07-14

Abstract excerpt

<h4>ABSTRACT</h4> The evolution of DNA methylome and methylation intra-tumor heterogeneity (ITH) during early carcinogenesis of lung adenocarcinoma has not been systematically studied. We perform reduced representation bisulfite sequencing of invasive lung adenocarcinoma and its precursors, atypical adenomatous hyperplasia, adenocarcinoma in situ and minimally invasive adenocarcinoma. We observe gradual increase o...

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Literature Corpus work: 440fc3d0-7250-5c44-8714-3034684e7f16
DOI: 10.1101/2020.07.11.20142745

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