Embryo-scale Visual Cell Sorting reveals a conserved transcriptomic signature of nucleolar size linked to proteostasis

Abstract excerpt

<h4>ABSTRACT</h4> Nucleoli, nuclear speckles and other compartments regulate transcription, RNA processing, and chromatin organization within the nucleus, yet the relationship of their morphology to developmental gene expression programs in vivo is poorly understood. Here, we develop a high-throughput Visual Cell Sorting (VCS) workflow for fixed cells and nuclei that combines antibody-based photoconversion; GPU-...

Topics

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• Active Transport, Cell Nucleus
• Cell Shape
• CRISPR-Cas Systems
• Genetic Techniques
• NF-kappa B
• Optical Imaging
• Organelles
• Transcription Factor RelA

Identifiers and source

Literature Corpus work

7d8d7d35-fb3a-58e7-a7c2-562d0653bce3

DOI

10.64898/2026.05.25.727721