Article

Deep-tissue spatial omics: imaging whole-embryo transcriptomics and subcellular structures at high spatial resolution

2024-05-17

Abstract excerpt

<h4>Summary</h4> The inherent limitations of fluorescence microscopy, notably the restricted number of color channels, have long constrained comprehensive spatial analysis in biological specimens. Here, we introduce cycleHCR technology that leverages multicycle DNA barcoding and Hybridization Chain Reaction (HCR) to surpass the conventional color barrier. cycleHCR facilitates high-specificity, single-shot imaging...

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Literature Corpus work: c5115519-606b-5e67-ab7e-f43b0cd360b2
DOI: 10.1101/2024.05.17.594641

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