Article
RAES：a rapid and high-fidelity method for artificial extrachromosomal circular DNA synthesis and its application as a bacterial DNA-free vector for robust microRNA overexpression
2023-08-23
Abstract excerpt
<title>Abstract</title> <p>Extrachromosomal circular DNA (eccDNA) has recently gained increasing attention due to its significant role in cancer and other pathological states. The majority of circular DNAs detected by Circle-seq are small-size eccDNAs with enigmatic functions. One major technical hurdle is to synthesize eccDNA for functional assessment. Here, we describe RAES (RCA-product dependent Artificial Ecc...
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Identifiers and source
- Literature Corpus work
- 7d768d2f-d0a7-5d3a-96cf-9d7f7d158866
- DOI
- 10.21203/rs.3.rs-3243746/v1