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Extrachromosomal circular MiR-17-92 amplicon promotes HCC

1 May 2023

Abstract excerpt

BACKGROUND AND AIMS: Extrachromosomal circular DNAs (eccDNAs) are prevalent in cancer genomes and emerge as a class of crucial yet less characterized oncogenic drivers. However, the structure, composition, genome-wide frequency, and contribution of eccDNAs in HCC, one of the most fatal and prevalent cancers, remain unexplored. In this study, we provide a comprehensive characterization of eccDNAs in human HCC and...

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PMID: 37125628
DOI: 10.1097/hep.0000000000000435

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