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Extrachromosomal circular DNAs are common and functional in esophageal squamous cell carcinoma

1 Sept 2021

Abstract excerpt

BACKGROUND: Esophageal squamous cell carcinoma (ESCC) is the leading cause of cancer-related mortality. While recent studies have documented the presence of extrachromosomal circular DNAs (eccDNAs) in various tumors, to date, there have been no studies examining the distribution and function of eccDNAs in ESCC. METHODS: The eccDNAs from three surgically matched ESCC tissue samples were extracted and amplified by...

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PMID: 34734016
DOI: 10.21037/atm-21-4372

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