Article
Extrachromosomal circular miRNA-gene amplifications contribute to the renal cancer phenotype.
Cell reports - 23 Dec 2025
Han Peng, Lv Wei, Xu Zhe, Yu Tianxi, Gao Shan, Xiang Xi, Pan Xiaoguang, Zeng Yuchen, Havgaard Jakob Hull, Gorodkin Jan, Liang Xue, Wu Shuang, Tao Huiying, Sui Xiaolong, Wang Wenting, Dong Wei, Yang Huanming, Lin Chunhua, Regenberg Birgitte
Abstract excerpt
Megabase-sized extrachromosomal circular DNA with intact oncogenes (ecDNA) plays crucial roles in cancer. However, the impact of smaller (100 bp-1 Mb), more ubiquitous extrachromosomal circular DNA (eccDNA) on tumor pathology is unclear. We analyze eccDNA from 122 renal tumors and adjacent tissues, finding increased eccDNA in late-stage cancers, correlating with heightened patient mortality and copy-number...
Read the complete abstract on PubMedTopics
- Humans
- MicroRNAs
- Kidney Neoplasms
- Phenotype
- Carcinoma, Renal Cell
- Gene Amplification