Article
Extrachromosomal circular DNA, microDNA, without canonical promoters produce short regulatory RNAs that suppress gene expression
2019-01-31
Abstract excerpt
<h4>ABSTRACT</h4> Interest in extrachromosomal circular DNA (eccDNA) molecules has increased recently because of their widespread presence in normal cells across every species ranging from yeast to humans, their increased levels in cancer cells, and their overlap with oncogenic and drug-resistant genes. However, the majority of eccDNA (microDNA) are too small to carry protein coding genes. We have tested function...
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Identifiers and source
- Literature Corpus work
- 5abda72c-0b56-5545-bc6c-1aa283288c8e
- DOI
- 10.1101/535831