Article

Recombinant ovine prion protein can be mutated at position 136 to improve its efficacy as an inhibitor of prion propagation

2022-07-25

Abstract excerpt

Prion diseases are progressive neurodegenerative disorders with no effective therapeutics. A central event leading to the pathology in the diseases is the conversion of PrP C into PrP Sc and its accumulation in the central nervous system. Previous studies demonstrated that PrP C , recombinant PrP (rPrP) and PrP peptides can inhibit the formation of PrP Sc . Here, the effectiveness of ovine rPrP mutants at codon 13...

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Literature Corpus work: 7d73ed4e-718f-5258-bf0a-4dd6e9d8830b
DOI: 10.21203/rs.3.rs-1846992/v1

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