Article
PCR-based detection of the polymorphism at codon 136 in the ovine prion protein gene.
Animal biotechnology - 1 Jan 2000
Lockley A K, Hosie B D, Moore L, Harling R, Bardsley R G
Abstract excerpt
In many breeds of sheep, a polymorphism at codon 136 of the prion protein gene has been shown to be strongly associated with the risk of developing scrapie. A single-step procedure for detecting this allelic variation is described here. When performed on a series of animals, the test was in complete agreement with their genotypes as had been previously determined by sequencing. The test is potentially easier and...
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