Article
Different allelic effects of the codons 136 and 171 of the prion protein gene in sheep with natural scrapie.
The Journal of general virology - 1 Aug 1995
Clouscard C, Beaudry P, Elsen J M, Milan D, Dussaucy M, Bounneau C, Schelcher F, Chatelain J, Launay J M, Laplanche J L
Abstract excerpt
Scrapie is a transmissible degenerative disease of the central nervous system occurring naturally in sheep. It belongs to the group of prion diseases also affecting man in which an abnormal isoform of the host-encoded prion protein (PrP) accumulating in the brain is responsible for neuronal death. Three main polymorphisms have been described in the sheep PrP gene, at positions 136, 154 and 171. A strong...
Topics
- Animals
- Arginine
- Base Sequence
- Codon
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Male
- Molecular Sequence Data
- Nematode Infections