Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased frequency of Ig heavy-chain HS1,2-A enhancer *2 allele in dermatitis herpetiformis, plaque psoriasis, and psoriatic arthritis.

The Journal of investigative dermatology - 1 Aug 2008

Cianci Rossella, Giambra Vincenzo, Mattioli Claudia, Esposito Maria, Cammarota Giovanni, Scibilia Graziella, Magazzù Giuseppe, Orlando Ambrogio, Sandri Giancarlo, Bianchi Luca, Gasbarrini Giovanni Battista, Pandolfi Franco, Frezza Domenico

Abstract excerpt

The enhancer DNase-hypersensitive region 1,2 (HS1,2), a member of the Ig heavy-chain 3' regulatory region (3'RR) cluster, is active in human B cells transfected with reporter genes and in mouse is activated in late maturation. HS1,2-A contains binding sites for several transcription factors. Ther...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Arthritis, Psoriatic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Base Sequence

Share to Case-Control Studies

Share to Enhancer Elements, Genetic

Share to Gene Frequency

Share to Immunoglobulin Heavy Chains

Share to Psoriasis

Source

Identifiers

PMID: 18323783
DOI: 10.1038/jid.2008.40

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18323783-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased frequency of Ig heavy-chain HS1,2-A enhancer *2 allele in dermatitis herpetiformis, plaque psoriasis, and psoriatic arthritis.PMID 18323783Read ↗

Polymorphism of immunoglobulin enhancer element HS1,2A: allele *2 associates with systemic sclerosis. Comparison with HLA-DR and DQ allele frequency.Semantic proximity Read ↗

Association between Psoriasis and haplotypes of the IgH 3' Regulatory Region 1.Semantic proximity Read ↗

Polymorphisms of the IgH enhancer HS1.2 and risk of systemic lupus erythematosus.Semantic proximity Read ↗

Allele *2 of the HS1,2A enhancer of the Ig regulatory region associates with rheumatoid arthritis.Semantic proximity Read ↗

Increased frequency of the immunoglobulin enhancer HS1,2 allele 2 in coeliac disease.Semantic proximity Read ↗

Allele *1 of HS1.2 enhancer associates with selective IgA deficiency and IgM concentration.Semantic proximity Read ↗

Genetic variants in IRF2, STAT6, and TSLP are associated with eczema herpeticum in a European cohort of patients with atopic dermatitisSemantic proximity Read ↗

Association between IgH enhancer hs1.2 and type 1 diabetes.Semantic proximity Read ↗

The functional VNTR of IGH enhancer HS1.2 associates with human longevity and interacts with TNFA promoter diplotype in a population of Central Italy.Semantic proximity Read ↗

Markers of psoriatic skin phenotype: androgen/estrogen and cortisone/cortisol imbalance, and DNA damageSemantic proximity Read ↗

Association between the response to B cell depletion therapy and the allele*2 of the HS1,2A enhancer in seropositive rheumatoid arthritis patients.Semantic proximity Read ↗

Dermatitis herpetiformis and celiac disease are both primarily associated with the HLA-DQ (alpha 1*0501, beta 1*02) or the HLA-DQ (alpha 1*03, beta 1*0302) heterodimers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.