Article
The Exonuclease Trex2 Shapes Psoriatic Phenotype.
The Journal of investigative dermatology - 1 Dec 2016
Manils Joan, Casas Eduard, Viña-Vilaseca Arnau, López-Cano Marc, Díez-Villanueva Anna, Gómez Diana, Marruecos Laura, Ferran Marta, Benito Carmen, Perrino Fred W, Vavouri Tanya, de Anta Josep Maria, Ciruela Francisco, Soler Concepció
Abstract excerpt
Trex2 is a keratinocyte-specific 3'-deoxyribonuclease that participates in the maintenance of skin homeostasis after DNA damage. Here, we show that this exonuclease is strongly upregulated in human psoriasis, a hyperproliferative and inflammatory skin disease. Similarly, the imiquimod (IMQ)- and Il23-induced mouse psoriasis was associated with a substantial upregulation of Trex2, which was recruited into...
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