Inflammatory reprogramming of the tumor microenvironment by infiltrating clonal hematopoiesis is associated with adverse outcomes in solid cancer

Abstract excerpt

Clonal hematopoiesis (CH) – the expansion of somatically-mutated hematopoietic cells in blood – is common in solid cancers. CH is associated with systemic inflammation that may lead to cancer, but its impact on tumor biology is underexplored. Here, we report the effects of CH on the tumor microenvironment (TME) using 1,550 treatment-naïve patient samples from the CPTAC cohort. CH was present in 18.3% of patients,...

Topics

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• Acute Myeloid Leukemia Research
• Clonal Hematopoiesis
• Disease Progression
• Hematopoiesis
• Mutation
• Neoplasms
• Risk Factors
• Tumor Microenvironment

Identifiers and source

Literature Corpus work

7d61c346-3666-5f82-b20d-4a888e86313c

DOI

10.1101/2024.08.29.24312110