Article

“UNTARGETING” AUTOANTIBODIES USING GENOME EDITING, A PROOF-OF-CONCEPT STUDY

2022-10-30

Abstract excerpt

Autoantibodies are useful biomarkers of autoimmune diseases and some have direct pathogenic role. Current standard therapies for elimination of specific B/plasma-cell clones are not fully efficient. In this proof-of-concept study, we used the CRISPR/Cas9 genome-editing system to knockout V(D)J rearrangements that produce pathogenic autoantibodies in vitro . HEK293T cell lines were established with stable express...

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Literature Corpus work: 7d45a253-08b8-5dd6-88a2-3fcee7a38020
DOI: 10.1101/2022.10.29.514381

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