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Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies.

PLoS biology - 1 Apr 2021

Zhu Xing, Mannar Dhiraj, Srivastava Shanti S, Berezuk Alison M, Demers Jean-Philippe, Saville James W, Leopold Karoline, Li Wei, Dimitrov Dimiter S, Tuttle Katharine S, Zhou Steven, Chittori Sagar, Subramaniam Sriram

Abstract excerpt

The recently reported "UK variant" (B.1.1.7) of SARS-CoV-2 is thought to be more infectious than previously circulating strains as a result of several changes, including the N501Y mutation. We present a 2.9-Å resolution cryo-electron microscopy (cryo-EM) structure of the complex between the ACE2 receptor and N501Y spike protein ectodomains that shows Y501 inserted into a cavity at the binding interface near Y41...

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Share to Angiotensin-Converting Enzyme 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33914735
DOI: 10.1371/journal.pbio.3001237
PMCID: PMC8112707

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