Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Computational investigation unveils pathogenic LIG3 non-synonymous mutations and therapeutic targets in acute myeloid leukemia

10 Jun 2025

Abstract excerpt

Single nucleotide polymorphisms (SNPs) in DNA repair genes can impair protein structure and function, contributing to disease development, including cancer. Non-synonymous SNPs (nsSNPs) in the LIG3 gene are linked to genomic instability and increased cancer risk, particularly acute myeloid leukemia (AML). This study aims to identify the most deleterious nsSNPs in the LIG3 and potential therapeutic targets for DNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Cancer Genomics and Diagnostics
Share to Chronic Lymphocytic Leukemia Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40493574
DOI: 10.1371/journal.pone.0320550

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Computational investigation unveils pathogenic LIG3 non-synonymous mutations and therapeutic targets in acute myeloid leukemiaPMID 40493574Read ↗

Computational investigation unveils pathogenic LIG3 non-synonymous mutations and therapeutic targets in acute myeloid leukemiaSemantic proximity Read ↗

Landscape of FLT3 Variations Associated with Structural and Functional Impact on Acute Myeloid Leukemia: A Computational Study.Semantic proximity Read ↗

Elucidating the Role of MLL1 nsSNPs: Structural and Functional Alterations and Their Contribution to Hematological Malignancies SusceptibilitySemantic proximity Read ↗

A computational approach to determine susceptibility to cancer by evaluating the deleterious effect of nsSNP in XRCC1 gene on binding interaction of XRCC1 protein with ligase III.Semantic proximity Read ↗

COSMIC Cancer Gene Census 3D database: understanding the impacts of mutations on cancer targets.Semantic proximity Read ↗

Identification of non-synonymous SNPs affecting structure and function of MLH1 and NBN proteins: a computational approach.Semantic proximity Read ↗

Twenty novel nsSNPs may affect <i>FLT3</i> gene leading to Acute Myeloid Leukemia (AML) using in silico analysisSemantic proximity Read ↗

Identification of non-synonymous SNPs Impacting Structure and Function of MLH1 and NBN Proteins: A computational approach.Semantic proximity Read ↗

Six novel nsSNPs affect <i>RUNX1</i> gene may leading to Acute Myeloid Leukemia (AML) using Bioinformatics approachSemantic proximity Read ↗

Mutational signatures in GATA3 transcription factor and its DNA binding domain that stimulate breast cancer and HDR syndrome.Semantic proximity Read ↗

Pathogenic Genetic Variants From Highly Connected Cancer Susceptibility Genes Confer the Loss of Structural StabilitySemantic proximity Read ↗

A novel NOTCH3 mutation identified in patients with oral cancer by whole exome sequencing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.