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Computational investigation unveils pathogenic LIG3 non-synonymous mutations and therapeutic targets in acute myeloid leukemia.

PloS one - 1 Jan 2025

Hossen Md Arif, Jahan Umme Mim Sad, Hossain Md Arju, Asif Khalid Hossain, Rahman Ahona, Ahmed Sabbir, Uddin Md Moin, Amin Md Faisal, Barik Muhammad Abdul, Islam Mohammod Johirul, Kamruzzaman Mohammad, Hasnat Soharth, Uddin Mohammad Nasir, Islam Tofazzal, Hoque M Nazmul

Abstract excerpt

Single nucleotide polymorphisms (SNPs) in DNA repair genes can impair protein structure and function, contributing to disease development, including cancer. Non-synonymous SNPs (nsSNPs) in the LIG3 gene are linked to genomic instability and increased cancer risk, particularly acute myeloid leukemia (AML). This study aims to identify the most deleterious nsSNPs in the LIG3 and potential therapeutic targets for DNA...

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Identifiers

PMID: 40493574
DOI: 10.1371/journal.pone.0320550
PMCID: PMC12151348

Genes

LIG3

Variants

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