Article

KDM6A mutations promote acute cytoplasmic DNA release, DNA damage response and mitosis defects

2021-02-09

Abstract excerpt

<title>Abstract</title> <p>Background KDM6A, encoding a histone demethylase, is one of the top ten mutated epigenetic cancer genes. The effect of mutations on its structure and function are however poorly characterized. Methods Database search identified nonsense and missense mutations in the N-terminal TPR motifs and the C-terminal, catalytic JmjC domain, but also in the intrinsically disordered region connect...

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Literature Corpus work: dc3a3641-177c-5715-a042-f2026616ee58
DOI: 10.21203/rs.3.rs-194379/v1

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