Article

Structural Perturbations and Destabilizing Mutations in RAD51C and RAD51D Reveal Mechanisms of Cancer Risk

2025-10-30

Abstract excerpt

<title>Abstract</title> <p>Breast and ovarian cancers remain among the most prevalent malignancies affecting women worldwide, with only 20% of hereditary cases explained by BRCA1/2 mutations. This highlights the importance of alternative susceptibility genes such as RAD51C and RAD51D, which play essential roles in homologous recombination repair (HRR). In this study, a comprehensive in silico analysis was conduct...

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Literature Corpus work: 1f272098-4bdc-5fc2-a31f-25eb98293f81
DOI: 10.21203/rs.3.rs-7450048/v1

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