Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prediction of deleterious non-synonymous SNPs of human MDC1 gene: an in silico approach.

Systems biology in reproductive medicine - 1 Dec 2024

Thote Vaishnavee, Dinesh Susha, Sharma Sameer

Abstract excerpt

MDC1 (Mediator of DNA damage Checkpoint protein 1) functions to facilitate the localization of numerous DNA damage response (DDR) components to DNA double-strand break sites. MDC1 is an integral component in preserving genomic stability and appropriate DDR regulation. There haven't been systematic investigations of MDC1 mutations that induce cancer and genomic instability. Variations in nsSNPs have the potential...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Cell Cycle Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Computational Biology

Share to Genomic Instability

Share to Melanoma

Share to Mutation

Share to Polymorphism, Single Nucleotide

Share to Skin Neoplasms

Source

Identifiers

PMID: 38630598
DOI: 10.1080/19396368.2024.2325699

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prediction of deleterious non-synonymous SNPs of human MDC1 gene: an in silico approach.PMID 38630598Read ↗

Functional defects of cancer-associated MDC1 mutations in DNA damage repair.Semantic proximity Read ↗

A computational approach to determine susceptibility to cancer by evaluating the deleterious effect of nsSNP in XRCC1 gene on binding interaction of XRCC1 protein with ligase III.Semantic proximity Read ↗

Integrative In Silico Analysis to Identify Functional and Structural Impacts of nsSNPs on Programmed Cell Death Protein 1 (PD-1) Protein and UTRs: Potential Biomarkers for Cancer SusceptibilitySemantic proximity Read ↗

In silico analysis of deleterious SNPs of human MTUS1 gene and their impacts on subsequent protein structure and function.Semantic proximity Read ↗

Structural Perturbations and Destabilizing Mutations in RAD51C and RAD51D Reveal Mechanisms of Cancer RiskSemantic proximity Read ↗

Identification and Computational Analysis of a Novel Pathogenic DKC1 Variant Underlying X-Linked Dyskeratosis Congenita.Semantic proximity Read ↗

Identification of non-synonymous SNPs Impacting Structure and Function of MLH1 and NBN Proteins: A computational approach.Semantic proximity Read ↗

Pathogenic Genetic Variants From Highly Connected Cancer Susceptibility Genes Confer the Loss of Structural StabilitySemantic proximity Read ↗

Pathogenic genetic variants from highly connected cancer susceptibility genes confer the loss of structural stability.Semantic proximity Read ↗

Investigation on the role of nsSNPs in HNPCC genes--a bioinformatics approach.Semantic proximity Read ↗

A comprehensive in silico investigation into the pathogenic SNPs in the RTEL1 gene and their biological consequences.Semantic proximity Read ↗

Identification of Damaging nsSNVs in HumanERCC2 Gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.