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Article

DNArCdb: A database of cancer biomarkers in DNA repair genes that includes variants related to multiple cancer phenotypes.

DNA repair - 1 Oct 2018

Silvestrov Pavel, Maier Sarah J, Fang Michelle, Cisneros G Andrés

Abstract excerpt

Functioning DNA repair capabilities are vital for organisms to ensure that the biological information is preserved and correctly propagated. Disruptions in DNA repair pathways can result in the accumulation of DNA mutations, which may lead to onset of complex disease such as cancer. The discovery and characterization of cancer-related biomarkers may allow early diagnosis and targeted treatment, which could...

Topics

Biomarkers, Tumor
DNA Polymerase I
DNA Repair
Databases, Genetic
Molecular Dynamics Simulation
Mutation
Mutation, Missense
Phenotype
Polymorphism, Single Nucleotide
Protein Conformation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Open in PubMed Open full text

Identifiers

PMID: 30098577
DOI: 10.1016/j.dnarep.2018.07.010
PMCID: PMC6151283

Genes

POLI
POLN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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