Article
Weakly deleterious natural genetic variation greatly amplifies probability of resistance in multiplexed gene drive systems
2021-12-23
Abstract excerpt
Evolution of resistance is a major barrier to successful deployment of gene drive systems to suppress natural populations, which could greatly reduce the burden of many vector borne diseases. Multiplexed guide RNAs that require resistance mutations in all target cut sites is a promising anti-resistance strategy, since in principle resistance would only arise in unrealistically large populations. Using novel stocha...
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Identifiers and source
- Literature Corpus work
- 7d172c88-71a6-5046-8df3-cb99b2e0fa61
- DOI
- 10.1101/2021.12.23.473701