Article

Exploiting the “survival of the likeliest” to enable evolution-guided drug design

2019-02-22

Abstract excerpt

<h4>Summary</h4> Theoretical treatments of evolutionary dynamics tend to model the probability that a single “resistant” species will arise in a population. However, experimental studies have identified a diversity of mutations that can lead to genetic resistance. By quantitatively predicting mutations that occur across an entire drug target during treatment, we identify and bridge a fundamental gap in drug resis...

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Literature Corpus work: abb7def8-6f6e-5090-a3b8-c44c0927dde5
DOI: 10.1101/557645

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