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Article

A theory of resistance to multiplexed gene drive demonstrates the significant role of weakly deleterious natural genetic variation.

Proceedings of the National Academy of Sciences of the United States of America - 9 Aug 2022

Khatri Bhavin S, Burt Austin

Abstract excerpt

Evolution of resistance is a major barrier to successful deployment of gene-drive systems to suppress natural populations, which could greatly reduce the burden of many vector-borne diseases. Multiplexed guide RNAs (gRNAs) that require resistance mutations in all target cut sites are a promising antiresistance strategy since, in principle, resistance would only arise in unrealistically large populations. Using...

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Identifiers

PMID: 35914131
DOI: 10.1073/pnas.2200567119
PMCID: PMC9371675

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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