Article

Evolution of Resistance Against CRISPR/Cas9 Gene Drive

2016-06-11

Abstract excerpt

The idea of driving genetically modified alleles to fixation in a population has fascinated scientists for over 40 years 1,2 . Potential applications are broad and ambitious, including the eradication of disease vectors, the control of pest species, and the preservation of endangered species from extinction 3 . Until recently, these possibilities have remained largely abstract due to the lack of an effective dri...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 15e657f9-4758-5071-93a0-df853228bea8
DOI: 10.1101/058438

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Evolution of Resistance Against CRISPR/Cas9 Gene DriveDOI 10.1101/058438Read

Evolutionary dynamics of CRISPR gene drivesSemantic proximity Read

Multiple loci of small effect confer wide variability in efficiency and resistance rate of CRISPR gene driveSemantic proximity Read

Novel CRISPR/Cas9 gene drive constructs reveal insights into mechanisms of resistance allele formation and drive efficiency in genetically diverse populations.Semantic proximity Read

Novel CRISPR/Cas9 gene drive constructs in <i>Drosophila</i> reveal insights into mechanisms of resistance allele formation and drive efficiency in genetically diverse populationsSemantic proximity Read

A CRISPR homing gene drive targeting a haplolethal gene removes resistance alleles and successfully spreads through a cage population.Semantic proximity Read

Current CRISPR gene drive systems are likely to be highly invasive in wild populations.Semantic proximity Read

Concerning RNA-Guided Gene Drives for the Alteration of Wild PopulationsSemantic proximity Read

Can a Population Targeted by a CRISPR-Based Homing Gene Drive Be Rescued?Semantic proximity Read

Concerning RNA-guided gene drives for the alteration of wild populations.Semantic proximity Read

Resistance is futile: A CRISPR homing gene drive targeting a haplolethal geneSemantic proximity Read

Reducing resistance allele formation in CRISPR gene drivesSemantic proximity Read

A transcomplementing gene drive provides a flexible platform for laboratory investigation and potential field deployment.Semantic proximity Read