Article
Phenome-wide Mendelian randomization study of plasma triglyceride levels and 2600 disease traits.
eLife - 29 Mar 2023
Park Joshua K, Bafna Shantanu, Forrest Iain S, Duffy Áine, Marquez-Luna Carla, Petrazzini Ben O, Vy Ha My, Jordan Daniel M, Verbanck Marie, Narula Jagat, Rosenson Robert S, Rocheleau Ghislain, Do Ron
Abstract excerpt
Background: Causality between plasma triglyceride (TG) levels and atherosclerotic cardiovascular disease (ASCVD) risk remains controversial despite more than four decades of study and two recent landmark trials, STRENGTH, and REDUCE-IT. Further unclear is the association between TG levels and non-atherosclerotic diseases across organ systems. Methods: Here, we conducted a phenome-wide, two-sample Mendelian...
Topics
- Humans
- Mendelian Randomization Analysis
- Phenotype
- Atherosclerosis
- Coronary Artery Disease
- Triglycerides
- Genome-Wide Association Study
- Polymorphism, Single Nucleotide