Article
Association of genetic variants related to combined lipid-lowering and antihypertensive therapies with risk of cardiovascular disease: 2 × 2 factorial Mendelian randomization analyses.
BMC medicine - 20 May 2024
Li Ying, Liu Hongwei, Shen Chong, Li Jianxin, Liu Fangchao, Huang Keyong, Gu Dongfeng, Li Yun, Lu Xiangfeng
Abstract excerpt
BACKGROUND: Lipid-lowering drugs and antihypertensive drugs are commonly combined for cardiovascular disease (CVD). However, the relationship of combined medications with CVD remains controversial. We aimed to explore the associations of genetically proxied medications of lipid-lowering and antihypertensive drugs, either alone or both, with risk of CVD, other clinical and safety outcomes. METHODS: We divided...
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