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Investigating pleiotropic effects of statins on ischemic heart disease in the UK Biobank using Mendelian randomisation

24 Aug 2020

Abstract excerpt

We examined whether specifically statins, of the major lipid modifiers (statins, proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors and ezetimibe) have pleiotropic effects on ischemic heart disease (IHD) via testosterone in men or women. As a validation, we similarly assessed whether a drug that unexpectedly likely increases IHD also operates via testosterone. Using previously published genetic...

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PMID: 32838838
DOI: 10.7554/elife.58567

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