Article

Expression of the long noncoding RNA DINO in HPV positive cervical cancer cells reactivates the dormant TP53 tumor suppressor through ATM/CHK2 signaling

2020-05-12

Abstract excerpt

<h4>ABSTRACT</h4> Tumor cells overcome the cytostatic and cytotoxic restraints of TP53 tumor suppressor signaling through a variety of mechanisms. High-risk human papillomavirus (HPV) positive tumor cells retain wild type TP53 because the HPV E6/UBE3A ubiquitin ligase complex targets TP53 for proteasomal degradation. While restoration of TP53 in tumor cells holds great promise for cancer therapy, attempts to func...

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Literature Corpus work: 7cc658b7-1794-530c-94c0-50bf6e904908
DOI: 10.1101/2020.05.08.085555

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