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Repression of human papillomavirus oncogenes in HeLa cervical carcinoma cells causes the orderly reactivation of dormant tumor suppressor pathways

7 Nov 2000

Abstract excerpt

Most cervical carcinomas express high-risk human papillomaviruses (HPVs) E6 and E7 proteins, which neutralize cellular tumor suppressor function. To determine the consequences of removing the E6 and E7 proteins from cervical cancer cells, we infected HeLa cells, a cervical carcinoma cell line that contains HPV18 DNA, with a recombinant virus that expresses the bovine papillomavirus E2 protein. Expression of the...

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Cancer-related Molecular Pathways
Cervical Cancer and HPV Research
Molecular Biology Techniques and Applications

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 11070078
DOI: 10.1073/pnas.97.23.12513

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Repression of human papillomavirus oncogenes in HeLa cervical carcinoma cells causes the orderly reactivation of dormant tumor suppressor pathwaysPMID 11070078Read ↗

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