Article

Identification of microRNAs that stabilize p53 in HPV-positive cancer cells

2020-09-21

Abstract excerpt

Etiologically, 5% of all cancers worldwide are caused by the high-risk human papillomaviruses (hrHPVs). These viruses encode two oncoproteins (E6 and E7) whose expression is required for cancer initiation and maintenance. Among their cellular targets are the p53 and the retinoblastoma tumor suppressor proteins. Inhibition of the hrHPV E6-mediated ubiquitylation of p53 through the E6AP ubiquitin ligase results in t...

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Literature Corpus work: 8cab2368-1365-51eb-8e60-9cc921be1508
DOI: 10.1101/2020.09.21.305946

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