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Article

p53-intact cancers escape tumor suppression through loss of long noncoding RNA Dino.

Cell reports - 29 Jun 2021

Marney Christina B, Anderson Erik S, Adnan Mutayyaba, Peng Kai-Lin, Hu Ya, Weinhold Nils, Schmitt Adam M

Abstract excerpt

Many long noncoding RNA (lncRNA) genes exist near cancer-associated loci, yet evidence connecting lncRNA functions to recurrent genetic alterations in cancer are lacking. Here, we report that DINO, the lncRNA transcribed from the cancer-associated DINO/CDKN1A locus, suppresses tumor formation independent of p21, the protein encoded at the locus. Loss of one or two alleles of Dino impairs p53 signaling and...

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Share to Cyclin-Dependent Kinase Inhibitor p21
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epistasis, Genetic

Share to Genes, Tumor Suppressor

Share to Genetic Loci

Share to Haploinsufficiency

Share to RNA, Long Noncoding

Share to Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 34192538
DOI: 10.1016/j.celrep.2021.109329
PMCID: PMC8287872

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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