Article

Differentiation-independent Activation of HPV Genome Replication by the lncRNA DINO

2026-06-19

Abstract excerpt

Human papillomaviruses (HPV) rely on multiple host cell factors to replicate the viral genome, yet the contribution of host long noncoding RNAs (lncRNAs) to viral genome maintenance and amplification in the productive life cycle remains poorly understood. In this study, we show that the lncRNA DINO is a driver of HPV DNA replication. DINO levels increase during keratinocyte differentiation and ectopic expression o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9e55ff93-d97a-5d15-a897-cb566286297b
DOI: 10.64898/2026.06.19.733329

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Differentiation-independent Activation of HPV Genome Replication by the lncRNA DINODOI 10.64898/2026.06.19.733329Read

Expression of the long noncoding RNA DINO in HPV positive cervical cancer cells reactivates the dormant TP53 tumor suppressor through ATM/CHK2 signalingSemantic proximity Read

Differentiation-Dependent Proximity Proteomics Identifies Novel Host Factors Linked to HPV16 E2 FunctionSemantic proximity Read

The Role of the DNA Damage Response throughout the Papillomavirus Life CycleSemantic proximity Read

p53-intact cancers escape tumor suppression through loss of long noncoding RNA Dino.Semantic proximity Read

E6AP is important for HPV E6’s role in regulating epithelial homeostasis and its loss impairs keratinocyte commitment to differentiationSemantic proximity Read

Papillomavirus genome structure, expression, and post-transcriptional regulationSemantic proximity Read

Virus-host interaction: investigating novel transcription factors involved in coupling HPV life cycle and epithelial differentiationSemantic proximity Read

RNA-Seq Analysis of Differentiated Keratinocytes Reveals a Massive Response to Late Events during Human Papillomavirus 16 Infection, Including Loss of Epithelial Barrier FunctionSemantic proximity Read

PRMT1 Modulates Alternative Splicing to Enhance HPV18 mRNA Stability and Promote the Establishment of InfectionSemantic proximity Read

Histone Variant macroH2A1 Spatially and Functionally Organizes Human Papillomavirus Replication Foci in the Productive Stage of InfectionSemantic proximity Read

Disruption of CTCF-YY1–dependent looping of the human papillomavirus genome activates differentiation-induced viral oncogene transcriptionSemantic proximity Read

The chromatin insulator CTCF regulates HPV18 transcript splicing and differentiation-dependent late gene expressionSemantic proximity Read