Article

Small molecule nonsense mediated mRNA decay and MDM2-p53 inhibitors synergistically induce apoptosis in cervical cancer cells

2022-04-12

Abstract excerpt

<h4>Purpose: </h4> Nonsense-mediated mRNA decay (NMD) pathway and p53 pathway, which play important roles in RNA quality control and cancer suppression respectively, are tightly related to tumorigenesis, and both are promising targets for tumor therapy. However, the impact of NMD inhibitor, p53-MDM2 inhibitor, and the combination of these two agents was poorly understood in cervical cancer. Methods Cell apoptosis...

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Literature Corpus work: dd2d0672-930f-592d-a3db-80279139f755
DOI: 10.21203/rs.3.rs-1533115/v1

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