Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA Damage Repair Genes Controlling Human Papillomavirus (HPV) Episome Levels under Conditions of Stability and Extreme Instability

2 Oct 2013

Abstract excerpt

DNA damage response (DDR) genes and pathways controlling the stability of HPV episomal DNA are reported here. We set out to understand the mechanism by which a DNA-binding, N-methylpyrrole-imidazole hairpin polyamide (PA25) acts to cause the dramatic loss of HPV DNA from cells. Southern blots revealed that PA25 alters HPV episomes within 5 hours of treatment. Gene expression arrays identified numerous DDR genes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cervical Cancer and HPV Research
Share to T-cell and Retrovirus Studies
Share to Vector-Borne Animal Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24098381
DOI: 10.1371/journal.pone.0075406

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA Damage Repair Genes Controlling Human Papillomavirus (HPV) Episome Levels under Conditions of Stability and Extreme InstabilityPMID 24098381Read ↗

Human Papillomavirus Episome Stability Is Reduced by Aphidicolin and Controlled by DNA Damage Response PathwaysSemantic proximity Read ↗

The Role of the DNA Damage Response throughout the Papillomavirus Life CycleSemantic proximity Read ↗

Recent Insights into the Control of Human Papillomavirus (HPV) Genome Stability, Loss, and DegradationSemantic proximity Read ↗

Why Human Papillomaviruses Activate the DNA Damage Response (DDR) and How Cellular and Viral Replication Persists in the Presence of DDR SignalingSemantic proximity Read ↗

Human Papillomaviruses Preferentially Recruit DNA Repair Factors to Viral Genomes for Rapid Repair and AmplificationSemantic proximity Read ↗

HPV induced R-loop formation represses innate immune gene expression while activating DNA damage repair pathwaysSemantic proximity Read ↗

Identification of several high-risk HPV inhibitors and drug targets with a novel high-throughput screening assaySemantic proximity Read ↗

p53-dependent R-loop formation and HPV pathogenesisSemantic proximity Read ↗

N 2-Alkyl-dG lesions elicit R-loop accumulation in the genomeSemantic proximity Read ↗

Identification of microRNAs that stabilize p53 in HPV-positive cancer cellsSemantic proximity Read ↗

Expression of the long noncoding RNA DINO in HPV positive cervical cancer cells reactivates the dormant TP53 tumor suppressor through ATM/CHK2 signalingSemantic proximity Read ↗

Engagement of the ATR-Dependent DNA Damage Response at the Human Papillomavirus 18 Replication Centers during the Initial AmplificationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.