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Article

Role of the DNA Damage Response in Human Papillomavirus RNA Splicing and Polyadenylation

12 Jun 2018

Abstract excerpt

Human papillomaviruses (HPVs) have evolved to use the DNA repair machinery to replicate its DNA genome in differentiated cells. HPV activates the DNA damage response (DDR) in infected cells. Cellular DDR factors are recruited to the HPV DNA genome and position the cellular DNA polymerase on the HPV DNA and progeny genomes are synthesized. Following HPV DNA replication, HPV late gene expression is activated....

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PMID: 29895741
DOI: 10.3390/ijms19061735

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