Article

<i>LRRK2</i>p.M1646T is associated with glucocerebrosidase activity and with Parkinson’s disease

2020-09-24

Abstract excerpt

<h4>Background and objectives</h4> The LRRK2 p.G2019S Parkinson’s disease (PD) variant is associated with elevated glucocerebrosidase (GCase) activity in peripheral blood. We aimed to evaluate the association of other LRRK2 variants with PD and its association with GCase activity. <h4>Methods</h4> LRRK2 and GBA were fully sequenced in 1,123 PD patients and 576 controls from the Columbia and PPMI cohorts, in which...

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Literature Corpus work: 7cae1078-6bcc-5460-9129-67f874ce106d
DOI: 10.1101/2020.09.23.20197558

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