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The <i>GBA1</i> p.E427K (p.E388K) Variant is a Risk Factor for Synucleinopathies: A Meta-Analysis

2026-03-18

Abstract excerpt

<h4>Background</h4> Variants in GBA1 are important genetic risk factors for synucleinopathies, including Parkinson’s disease (PD). While several GBA1 variants are established risk or severity modifiers, the role of the p.E427K variant remains unclear. <h4>Objective: </h4> To determine whether the GBA1 p.E427K variant is associated with risk of synucleinopathies. <h4>Methods</h4> We performed a meta-analysis...

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Literature Corpus work
5c6a9172-48d4-56f9-8ff7-3499d4ac55d8
DOI
10.64898/2026.03.18.26347268
Open publication

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