Article

Clinical and functional evidence for the pathogenicity of the LRRK2 p.Arg1067Gln variant

2024-09-17

Abstract excerpt

<title>Abstract</title> <p>LRRK2-related Parkinson’s disease (LRRK2-PD) is the most frequent form of monogenic PD worldwide, with important therapeutic opportunities, exemplified by the advancement in LRRK2 kinase inhibition studies/trials. However, many LRRK2 variants, especially those found in underrepresented populations, remain classified as variants of uncertain significance (VUS). Leveraging on Malaysian, S...

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Literature Corpus work: 80e3a397-6c4d-576c-8371-621a82c2a542
DOI: 10.21203/rs.3.rs-4920792/v1

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