Association Between Glucocerebrosidase Mutations and Parkinson's Disease in Ireland

Abstract excerpt

Multiple studies implicate heterozygous GBA mutations as a major genetic risk factor for PD, however the frequency of mutations has never been examined in PD patients from the Irish population. We prospectively recruited 314 unrelated Irish PD patients (UK Brain Bank Criteria) and 96 Irish healthy controls (without any signs or family history of parkinsonism) attending The Dublin Neurological Institute (DNI)....

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