Article
Longitudinal Measurements of Glucocerebrosidase activity in Parkinson's patients.
Annals of clinical and translational neurology - 1 Oct 2020
Alcalay Roy N, Wolf Pavlina, Chiang Ming Sum Ruby, Helesicova Karolina, Zhang Xiaokui Kate, Merchant Kalpana, Hutten Samantha J, Scherzer Clemens, Caspell-Garcia Chelsea, Blauwendraat Cornelis, Foroud Tatiana, Nudelman Kelly, Gan-Or Ziv, Simuni Tanya, Chahine Lana M, Levy Oren, Zheng Dandi, Li Gen, Sardi Sergio Pablo
Abstract excerpt
OBJECTIVE: Reduction in glucocerebrosidase (GCase; encoded by GBA) enzymatic activity has been linked to Parkinson's disease (PD). Here, we correlated GCase activity and PD phenotype in the Parkinson's Progression Markers Initiative (PPMI) cohort. METHODS: We measured GCase activity in dried blood spots from 1559 samples of participants in the inception PPMI cohort, collected in four annual visits (from baseline...
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